This doesn't mean it's unsafe it means it hasn't gone through the specific regulatory pathway the FDA requires for approved drugs
The problem is that many critical peptide levels decline as you age
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Additionally, lacosamide, an approved drug for treating epilepsy, has also been reported to induce histone hyperacetylation via reductions of HDACs protein expressions, enhancement of histone acetyltransferase or HDAC inhibition by its metabolites [48, 49]
IGF-1 LR3: mechanism and evidence base IGF-1 LR3 (insulin-like growth factor 1 long arginine 3) is an 83-amino-acid synthetic analogue of human IGF-1 in which glutamic acid at position 3 is replaced with arginine and an additional 13-amino-acid extension is appended to the N-terminus
Although it is not known whether P-glycoprotein is able to transport AFB 1 the broad specificity of this efflux pump and its activity towards hydrophobic drugs suggests that this is likely